Can I read Topiramate reduces levodopa-induced dyskinesia in the MPTP-lesioned marmoset model of Parkinson's disease on EtoBox?

Topiramate reduces levodopa-induced dyskinesia in the MPTP-lesioned marmoset model of Parkinson's disease by Monty A. Silverdale; S.L. Nicholson; A.R. Crossman; J.M. Brotchie is a Medicine article available to read on EtoBox.

What is Topiramate reduces levodopa-induced dyskinesia in the MPTP-lesioned marmoset model of Parkinson's disease about?

## Abstract Overactive AMPA receptor‐mediated transmission may be involved in the pathogenesis of levodopa‐induced dyskinesia. The mechanism of action of the anticonvulsant drug topiramate involves attenuation of AMPA receptor‐mediated transmission. In this study, the potential antidyskinetic action of topiramate was examined in the MPTP‐lesioned marmoset model of Parkinson's disease and levodopa‐induced dyskinesia. Topiramate significantly reduced levodopa‐induced dyskinesia, without affecting the antiparkinsonian action of levodopa. Topiramate represents an exciting potential novel therapeutic approach to levodopa‐induced dyskinesia in patients with Parkinson's disease. © 2004 Movement Disorder Society

Who reads Topiramate reduces levodopa-induced dyskinesia in the MPTP-lesioned marmoset model of Parkinson's disease?

Author

Monty A. Silverdale; S.L. Nicholson; A.R. Crossman; J.M. Brotchie

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

2004

Language

EN

Field

Medicine (Health Sciences)