Can I read PAX6 intronic sequence targets expression to the spinal cord on EtoBox?
PAX6 intronic sequence targets expression to the spinal cord by Zheng-Ping Xu; Grady F. Saunders is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is PAX6 intronic sequence targets expression to the spinal cord about?
PAX6, a member of the family of highly conserved paired-box and homeobox genes, is highly conserved at both the protein and DNA levels. A conserved 216-bp Pax6 intron 4 sequence was found in human, mouse, and quail. Our transgenic mice experiments indicated that when under control of the human PAX6 promoter, the human 216-bp conserved sequence (ele4H) functioned as a spinal cord-specific enhancer. This enhancer can drive lacZ expression at the thoracic and lumbar levels of the spinal cord only when linked to a functional PAX6 promoter. These studies also suggested that PAX6 was not only conserved at the functional level, but at the transcriptional level as well. Dev.
Who reads PAX6 intronic sequence targets expression to the spinal cord?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Zheng-Ping Xu; Grady F. Saunders
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0192-253X)
- Published
- 1999
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)