Can I read A profile of impaired insulin degradation in relation to late-life cognitive decline: A preliminary investigation on EtoBox?

A profile of impaired insulin degradation in relation to late-life cognitive decline: A preliminary investigation by Olivia I. Okereke; Dennis J. Selkoe; Michael N. Pollak; Meir J. Stampfer; Frank B. Hu; Susan E. Hankinson; Francine Grodstein is a Medicine article available to read on EtoBox.

What is A profile of impaired insulin degradation in relation to late-life cognitive decline: A preliminary investigation about?

## Abstract ## Objective Insulin degradation pathways may be related to Alzheimer's disease pathology. In preliminary analyses, we considered the relation of combined lower insulin secretion (c‐peptide) and higher insulin––possibly a phenotype for impaired insulin degradation––to cognitive decline. ## Method Fasting plasma c‐peptide and insulin were measured in 1,187 non‐diabetic Nurses' Health Study participants (mean age = 64 years). Cognitive testing began 10 years later. Participants completed three repeated assessments (over an average span of 4.4 years) of verbal memory, a strong predictor of Alzheimer disease development. C‐peptide and insulin distributions were dichotomized at their medians to create four cross‐tabulated categories. Multivariable linear mixed effects models were used to relate c‐peptide/insulin categories to cognitive decline. ## Results Compared to the lower c‐peptide/lower insulin group, women with lower c‐peptide/higher insulin had a significantly faster rate of verbal memory decline: the mean difference was ‐0.05 units/year (95% CI ‐0.09,‐0.01). This mean difference was similar to that which we found for women 5 years apart in age, indicating that havin

Who reads A profile of impaired insulin degradation in relation to late-life cognitive decline: A preliminary investigation?

Author

Olivia I. Okereke; Dennis J. Selkoe; Michael N. Pollak; Meir J. Stampfer; Frank B. Hu; Susan E. Hankinson; Francine Grodstein

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0885-6230)

Published

2008

Language

EN

Field

Medicine (Health Sciences)