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Controlled... 1 Abstract 1 Abstract 1 Abstract 1 Abstract 1 Abstract 1 INTRODUCTION 1 MATERIALS AND METHODS 3 Materials 3 Methods 3 Preparation of Ibuprofen-Ddex Nanoconjugates 3 Zeta Potential of Ibuprofen-Dex Nanoconjugates 3 Ibuprofen-Ddex Conjugation Efficiency 3 Morphological Characteristics of Ibuprofen-Ddex Nanoconjugates Using Scanning Electron Microscope (SEM) 4 Fourier Transforms Infrared Spectroscopy (FT-IR) 4 Differential Scanning Calorimetry (DSC) 4 Thermal Gravimetry Analysis (TGA) 4 NMR Spectroscopy 4 In Vitro Release Kinetics 4 Mechanism of Ibuprofen Release from Ibuprofen-Ddex Nanoconjugate 5 Statistical Analysis 5 RESULTS AND DISCUSSION 5 Formulation and Optimization of Ibuprofen-Ddex Self-Assembled Nanoconjugates 5 Surface Morphology and Particle Size Analysis of Ibuprofen-Ddex Nanoconjugates 7 Conjugation Efficiency 7 Characterization of Ibuprofen-Ddex Nanoconjugate 9 FT-IR Spectra Analysis 9 1H NMR and 13C NMR Spectra Analyses 9 Thermo-Analytical Characteristics of Ibuprofen-Ddex Nanoconjugates 11 Dissolution Studies 15 Evaluation of System-Specific In Vitro Parameters and Mechanism of Ibuprofen Release from the Nanoconjugate 17 Mechanism of Ibuprofen Release f

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3B2 Total Publishing System 8.07e/W Unicode

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EN