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LC–MS/MS studies of ritonavir and its forced degradation products by R. Nageswara Rao; B. Ramachandra; R. Mastan Vali; S. Satyanarayana Raju is a Chemistry article available to read on EtoBox.

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Forced degradation of ritonavir (RTV), under the conditions of hydrolysis (acidic, basic and neutral), oxidation, photolysis and thermal stress as prescribed by ICH was studied using LC-MS/MS. Eight degradation products were formed and their separation was accomplished on Waters XTerra ® C 18 column (250 mm × 4.6 mm i.d., 5 m) using water:methanol:acetonitrile as (40:20:40, v/v/v) mobile phase in an isocratic elution mode by LC. The method was extended to LC-MS/MS for characterization of the degradation products and the pathways of decomposition were proposed. No previous reports were found in the literature regarding the characterization of degradation products of ritonavir.

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Author

R. Nageswara Rao; B. Ramachandra; R. Mastan Vali; S. Satyanarayana Raju

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)

Published

2010

Language

EN

Field

Chemistry (Physical Sciences)