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Evidence that polymorphic deletion of the glutathione S-transferase gene, GSTM1, is associated with esophageal atresia by Laura Filonzi; Cinzia Magnani; Gian Luigi de' Angelis; Sara Dallaglio; Francesco Nonnis Marzano is a Medicine article available to read on EtoBox.
What is Evidence that polymorphic deletion of the glutathione S-transferase gene, GSTM1, is associated with esophageal atresia about?
## Abstract ## BACKGROUND: Esophageal atresia (EA) is a life‐threatening congenital condition whose etiology and pathogenesis are still poorly understood. An increasing trend of this pathology in some Italian regions suggests a possible interaction between xenobiotics and genes involved in detoxification processes during early embryonic development. For the first time polymorphisms of __GSTM1, GSTT1__, and __GSTP1__ genes were analyzed in association with EA. ## METHODS: The study population consisted of 25 EA children, 50 unrelated healthy children, 20 of the EA children's mothers, and 40 unrelated mothers. __GSTM1__ and __GSTT1__ null genotypes were identified by PCR amplification, and __GSTP1__ polymorphism was detected by RFLP analysis. ## RESULTS: An association was found between homozygosity for the __GSTM1__ null genotype and EA in affected children (__p__ = 0.0022) and their mothers (__p__ = 0.022). No association was found between __GSTT1__ and __GSTP1__ polymorphisms and EA children or their mothers. ## CONCLUSIONS: Results suggest that the __GSTM1__^−/−^ null genotype may play an important role in the development of EA during early embryogenesis as a consequence of alter
Who reads Evidence that polymorphic deletion of the glutathione S-transferase gene, GSTM1, is associated with esophageal atresia?
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- Author
- Laura Filonzi; Cinzia Magnani; Gian Luigi de' Angelis; Sara Dallaglio; Francesco Nonnis Marzano
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1542-0752)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)