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Probiotics Improve Polystyrene Microplastics-induced Male Reproductive Toxicity in Mice by Alleviating Inflammatory Response by Yecui Zhang; Baolian Hou; Tao Liu; Yanling Wu; Zhiping Wang is a Environmental Science article available to read on EtoBox.

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As a new type of environmental pollutant, microplastics have been garnered increasing attention, especially in regard to their effects on the reproductive system. However, researchers have yet to report whether prevention and treatment measures exist for reproductive injury caused by microplastics. The aim of this study was therefore to explore the mechanism of spermatogenic injury induced by polystyrene microplastics (PS-MPs) and the intervention effect of probiotics based on the gut microbiota-testis axis. Mice were orally exposed for 35 days to 5 μm of PS-MPs with a gavage dose was 0.1 mg/day, and the intervention group was given probiotics (Lactobacillus, Bifidobacterium longum, and Enterococcus) orally. Fecal samples were then subjected to 16 S rRNA sequencing analysis, and sperm motion was analyzed by a Hamilton-Thorne Sperm analyzer. The results showed that PS-MPs exposed mice had significant spermatogenic dysfunction and testicular inflammation. In addition, the intestinal microbial structure of exposed mice changed significantly; the abundance of Lactobacillus decreased, and the abundance of Prevotella increased. Furthermore, with fecal microbiota transplantation, the reci

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Author

Yecui Zhang; Baolian Hou; Tao Liu; Yanling Wu; Zhiping Wang

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Environmental Science (Physical Sciences)