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Human FGF‐1 gene delivery protects against quinolinate‐induced striatal and hippocampal injury in neonatal rats by Mir Ahamed Hossain; Kevin E. Fielding; William H. Trescher; Tang Ho; Mary Ann Wilson; John Laterra is a Neuroscience article available to read on EtoBox.

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## Abstract Fibroblast growth factors (FGFs) are cell mitogens and differentiating factors with neuroprotective properties in the CNS. We have already shown that endothelial cells genetically engineered to secrete human FGF‐1 (RBEZ‐FGF) survive implantation to neonatal rat brain (Johnston __et al__. (1996) __J. Neurochem.__67, 1643–1652]. In this study, the effects of cell‐based FGF‐1 gene delivery on quinolinate‐induced neurotoxicity in the developing rat brain were examined. Control endothelial cells (RBE4), and RBEZ‐FGF cells were implanted into right striatum at post‐natal day (PND) 7. On PND 10, quinolinate (150 nmol), an endogenous __N__‐methyl‐d‐aspartate (NMDA) receptor agonist, or vehicle alone was injected into striatum ipsilateral to cell implantation. Injury was quantified in coronal sections obtained from PND 17 animals by comparing striatal and hippocampal volumes ipsilateral and contralateral to the site of quinolinate injection. Human FGF‐1 specific transgene expression __in vivo__ was shown by Northern blot and RT‐PCR up to 14 days after cell implantation in control animals, and up to 4 days after quinolinate exposure. Quinolinate reduced the size of ipsilateral st

Who reads Human FGF‐1 gene delivery protects against quinolinate‐induced striatal and hippocampal injury in neonatal rats?

Author

Mir Ahamed Hossain; Kevin E. Fielding; William H. Trescher; Tang Ho; Mary Ann Wilson; John Laterra

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

1998

Language

EN

Field

Neuroscience (Life Sciences)