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Multimodal Characterization of Cardiac Organoids Using Integrations of Pressure-Sensitive Transistor Arrays with Three-Dimensional Liquid Metal Electrodes by Moohyun Kim; Jae Chul Hwang; Sungjin Min; Young-Geun Park; Suran Kim; Enji Kim; Hunkyu Seo; Won Gi Chung; Jakyoung Lee; Seung-Woo Cho; Jang-Ung Park is a Engineering article available to read on EtoBox.
What is Multimodal Characterization of Cardiac Organoids Using Integrations of Pressure-Sensitive Transistor Arrays with Three-Dimensional Liquid Metal Electrodes about?
Herein, we present an unconventional method for multimodal characterization of three-dimensional cardiac organoids. This method can monitor and control the mechanophysiological parameters of organoids within a single device. In this method, local pressure distributions of human-induced pluripotent stem-cell-derived cardiac organoids are visualized spatiotemporally by an active-matrix array of pressure-sensitive transistors. This array is integrated with three-dimensional electrodes formed by the high-resolution printing of liquid metal. These liquid-metal electrodes are inserted inside an organoid to form the intraorganoid interface for simultaneous electrophysiological recording and stimulation. The low mechanical modulus and low impedance of the liquid-metal electrodes are compatible with organoids’ soft biological tissue, which enables stable electric pacing at low thresholds. In contrast to conventional electrophysiological methods, this measurement of a cardiac organoid’s beating pressures enabled simultaneous treatment of electrical therapeutics using a single device without any interference between the pressure signals and electrical pulses from pacing electrodes, even in we
Who reads Multimodal Characterization of Cardiac Organoids Using Integrations of Pressure-Sensitive Transistor Arrays with Three-Dimensional Liquid Metal Electrodes?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Moohyun Kim; Jae Chul Hwang; Sungjin Min; Young-Geun Park; Suran Kim; Enji Kim; Hunkyu Seo; Won Gi Chung; Jakyoung Lee; Seung-Woo Cho; Jang-Ung Park
- Publisher
- American Chemical Society (ACS)
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)