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NBS-Mediated Synthesis of Imidazo[1,2-a]pyridines by Antônio Neto Machado is a document available to read on EtoBox.
What is NBS-Mediated Synthesis of Imidazo[1,2-a]pyridines about?
The document describes a new protocol for synthesizing various N-bridged fused heterocycles, including imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrimidines, and imidazo[2,1-b]thiazole. The reaction involves the in situ formation of alpha-brominated intermediates of aromatic ketones, 1,3-diketones, or beta-keto esters using N-bromosuccinimide, followed by trapping with nucleophiles to form the heterocyclic products in good yields under metal-free conditions in water. The new protocol provides an
- Author
- Antônio Neto Machado
- Language
- EN