About this document
Introduction to Drug Design Principles by DrHamad is a document available to read on EtoBox.
This document discusses strategies for drug design and optimization. It covers improving pharmacokinetic properties like solubility, permeability, stability and targeting through various chemical modifications. Some key strategies discussed include: 1) Varying alkyl groups to change hydrophilic/lipophilic balance. 2) Adding or removing polar groups to increase or decrease solubility. 3) Introducing groups to block susceptible metabolic sites and increase stability. 4) Shifting positions of metabolica
- Author
- DrHamad
- Language
- EN