Opening book details…
Can I read Expression of β-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells on EtoBox?
Expression of β-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells by Louise A. Duits; Bep Ravensbergen; Mirjam Rademaker; Pieter S. Hiemstra; Peter H. Nibbering is a Immunology and Microbiology article available to read on EtoBox.
What is Expression of β-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells about?
## Summary Human β‐defensins are broad‐spectrum antimicrobial peptides known to be produced by epithelial cells. It was recently shown that β‐defensins also display chemotactic activity for dendritic cells (DC) and T cells, and thus may serve to link innate and adaptive immunity. The aim of the present study was to explore expression of mRNA for these peptides in mononuclear phagocytes and DC. The results revealed that monocytes, monocyte‐derived‐macrophages (MDM), and monocyte‐derived‐dendritic cells (DC) all express human‐β‐defensin‐1 (hBD‐1) mRNA. hBD‐1 mRNA expression by monocytes and MDM was increased after activation with interferon‐γ (IFN‐γ) and/or lipopolysaccharide (LPS) in a dose‐ and time‐dependent fashion. Alveolar macrophages showed an intense hBD‐1 expression, which could not be further increased. Expression of hBD‐1 mRNA by immature DC was low, and increased considerably after maturation. Monocytes, MDM, alveolar macrophages and DC showed a limited expression of human β‐defensin‐2 (hBD‐2) mRNA, which could only be increased in monocytes and alveolar macrophages by IFN‐γ and/or LPS in a dose‐ and time‐dependent fashion. Immunocytochemical stainings demonstrated the ex
Who reads Expression of β-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Louise A. Duits; Bep Ravensbergen; Mirjam Rademaker; Pieter S. Hiemstra; Peter H. Nibbering
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0019-2805)
- Published
- 2002
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)