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Long-term Lansoprazole Treatment for Gastro-oesophageal Reflux Disease: Clinical Efficacy and Influence on Gastric Mucosa by K. Geboes; W. Dekker; C. J. J. Mulder; K. Nusteling; (ON BEHALF OF THE DUTCH STUDY GROUP) is a Medicine article available to read on EtoBox.

What is Long-term Lansoprazole Treatment for Gastro-oesophageal Reflux Disease: Clinical Efficacy and Influence on Gastric Mucosa about?

## Background: Long‐term acid suppression is believed to accelerate atrophic gastritis in __Helicobacter pylori__‐positive patients. The influence of long‐term therapy with lansoprazole has not been examined. ## Aim: To study the clinical and endoscopic efficacy and histological evolution of gastric mucosa during 5 years of maintenance treatment with lansoprazole, 30 mg. ## Methods: Seventy‐eight patients with endoscopically proven oesophagitis were followed for 5 years. Biopsies taken at the start of the study, during follow‐up and after 5 years were available for 73 patients. ## Results: The total endoscopic relapse rate was 14.1%. At the start of the study, 34 patients were __Helicobacter pylori__ negative and 39 were __Helicobacter pylori__ positive (two atrophy, 25 antral gastritis, 12 pangastritis). At 5 years, no histological changes had occurred in __Helicobacter pylori__‐negative patients. In the __Helicobacter pylori__‐positive group, 20 patients developed pangastritis, six had normal histology and one had antral gastritis. Ten of the 12 patients with pangastritis had reduced antral activity. There was no increase in intestinal metaplasia, but there was a tendency towards

Who reads Long-term Lansoprazole Treatment for Gastro-oesophageal Reflux Disease: Clinical Efficacy and Influence on Gastric Mucosa?

Author

K. Geboes; W. Dekker; C. J. J. Mulder; K. Nusteling; (ON BEHALF OF THE DUTCH STUDY GROUP)

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

2001

Language

EN

Field

Medicine (Health Sciences)