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Can I read Inhibition of off-target cleavage by RNase H using an artificial cationic oligosaccharide on EtoBox?
Inhibition of off-target cleavage by RNase H using an artificial cationic oligosaccharide by Rintaro Iwata Hara; Takeshi Wada is a Chemistry article available to read on EtoBox.
What is Inhibition of off-target cleavage by RNase H using an artificial cationic oligosaccharide about?
Sequence-dependent off-target effects are a serious problem of antisense oligonucleotide-based drugs. Some of these side effects are induced by ribonuclease H (RNase H)-mediated cleavage of non-target RNAs with base sequences similar to that of the target RNA. We found that an artificial cationic oligosaccharide, ODAGal4, improved single-base discrimination for RNase H cleavage.
Who reads Inhibition of off-target cleavage by RNase H using an artificial cationic oligosaccharide?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Rintaro Iwata Hara; Takeshi Wada
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)