Opening book details…
Can I read Changes in Gene Expression Profiles and Cytokine Secretions in Peripheral Monocytes by Treatment with Small Extracellular Vesicles Derived from a Canine Lymphoma Cell Line on EtoBox?
Changes in Gene Expression Profiles and Cytokine Secretions in Peripheral Monocytes by Treatment with Small Extracellular Vesicles Derived from a Canine Lymphoma Cell Line by Akiyoshi TANI; Hirotaka TOMIYASU; Hajime ASADA; Chen-Si LIN; Yuko GOTO-KOSHINO; Koichi OHNO; Hajime TSUJIMOTO is a Medicine article available to read on EtoBox.
What is Changes in Gene Expression Profiles and Cytokine Secretions in Peripheral Monocytes by Treatment with Small Extracellular Vesicles Derived from a Canine Lymphoma Cell Line about?
Interactions between tumor and immune cells within the tumor microenvironment play an important role in tumor progression, and small extracellular vesicles (EVs) derived from these tumor cells have been shown to exert immunomodulatory effects on various immune cells, including macrophages and lymphocytes. Although the immunomodulatory effects of small EVs derived from human cancer cells have been intensively investigated, few studies have investigated the effects of lymphoma-derived small EVs on macrophages in both human and veterinary medicine. Here, we evaluated the effects of canine lymphoma-derived small EVs on canine primary monocytes, which are the major source of macrophages in neoplastic tissues. Comprehensive gene expression analysis of these treated monocytes revealed their distinct activation via the Toll-like receptor (TLR) and NF-κβ signaling pathways. In addition, treatment with lymphoma small EVs increased the secretion of MCP-1, which induces the infiltration and migration of monocytes and lymphocytes in neoplastic and cancer tissues. The results of this study indicate that canine lymphoma small EVs activate monocytes, possibly through the activation of TLR and NF-κ
Who reads Changes in Gene Expression Profiles and Cytokine Secretions in Peripheral Monocytes by Treatment with Small Extracellular Vesicles Derived from a Canine Lymphoma Cell Line?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Akiyoshi TANI; Hirotaka TOMIYASU; Hajime ASADA; Chen-Si LIN; Yuko GOTO-KOSHINO; Koichi OHNO; Hajime TSUJIMOTO
- Publisher
- Japanese Society of Veterinary Science
- Published
- 2022
- Language
- EN
- Field
- Medicine (Life Sciences)