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Somatic genetic alterations in BRCA2-associated and sporadic male breast cancer by Mika Tirkkonen; Tommi Kainu; Niklas Loman; Óskar T. Jóhannsson; Håkan Olsson; Rósa B. Barkardóttir; Olli-P. Kallioniemi; Åke Borg is a Medicine article available to read on EtoBox.
What is Somatic genetic alterations in BRCA2-associated and sporadic male breast cancer about?
The genetic changes underlying the development and progression of male breast cancer are poorly understood. Germline BRCA2 mutations account for a significant part of male breast cancer, but the majority of patients lack a known inherited predisposition. We recently demonstrated that the progression of breast cancer in female carriers of a germline BRCA1 or BRCA2 mutation follows specific genetic pathways, distinct from each other and from sporadic breast cancer. In the present study, we performed a genome-wide survey by comparative genomic hybridization (CGH) of somatic genetic aberrations in 26 male breast cancers, including five tumors from BRCA2 mutation carriers. BRCA2 tumors exhibited a significantly higher number of chromosomal aberrations than sporadic tumors. The most common alterations in sporadic male breast cancer were ϩ1q (38%), ϩ8q (33%), ϩ17q (33%), -13q (29%), and -8p (24%). In tumors from BRCA2 mutation carriers, the five most common genetic changes were ϩ8q (100%), ϩ20q (100%), ϩ17q (80%), -13q (80%), and -6q (60%). The CGH results in these two groups of male breast cancers are almost identical to those identified in the corresponding sporadic and BRCA2-associated
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- Author
- Mika Tirkkonen; Tommi Kainu; Niklas Loman; Óskar T. Jóhannsson; Håkan Olsson; Rósa B. Barkardóttir; Olli-P. Kallioniemi; Åke Borg
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Life Sciences)