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Nitric Oxide and Proteoglycan Turnover in Rabbit Articular Cartilage by M. Stefanovic-Racic; M. O. Möllers; L. A. Miller; C. H. Evans is a Medicine article available to read on EtoBox.

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## Abstract Articular chondrocytes are known to synthesize large amounts of nitric oxide in response to exposure to interleukin‐1, but the role of this radical in proteoglycan turnover remains controversial. In this study, we used two different inhibitors of nitric oxide synthase, N^G^‐methyl‐L‐arginine and thiocitrulline, to study the effects of nitric oxide on the synthesis and breakdown of proteoglycan in rabbit articular cartilage. Synthes of nitric oxide by cartilage slices in response to treatment with interleukin‐1 and a partially purified mixture of synovial cytokines known as chondrocyte‐activating factors peaked during the first 2 days of culture and then fell to low levels, despite daily replenishment with fresh medium and cytokines to the cultures. The production of nitric oxide was completely inhibited by N^G^‐methyl‐L‐arginine and thiocitrulline. Interleukin‐1 and the chondrocyte‐activating factors inhibited proteoglycan synthesis and accelerated proteoglycan breat down in the slices of cartilage. Both nitric oxide synthase inhibitors substantially counteracted the suppression of prdteoglycan synthesis but exacerbated proteoglycan catabolism occurring in response to i

Who reads Nitric Oxide and Proteoglycan Turnover in Rabbit Articular Cartilage?

Author

M. Stefanovic-Racic; M. O. Möllers; L. A. Miller; C. H. Evans

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)

Published

1997

Language

EN

Field

Medicine (Health Sciences)