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Polymorphisms in arsenic (+ 3 oxidation state) methyltransferase (AS3MT) predict the occurrence of hyperleukocytosis and arsenic metabolism in APL patients treated with As2O3 by Liu, Wen-Sheng; Wang, Xin-Yu; Lu, Jing; Zhang, Ying-Mei; Ye, Xiang-Mei; Li, Jin-Mei; Zhao, Qi-Lei; Wu, Zhi-Qiang; Zhou, Jin; Hai, Xin is a Environmental Science article available to read on EtoBox.
What is Polymorphisms in arsenic (+ 3 oxidation state) methyltransferase (AS3MT) predict the occurrence of hyperleukocytosis and arsenic metabolism in APL patients treated with As2O3 about?
Polymorphisms in arsenic (+ 3 oxidation state) methyltransferase (AS3MT) have been shown to be related to interindividual variations in arsenic metabolism and to influence adverse health effects in acute promyelocytic leukemia (APL) patients treated with arsenic trioxide (As 2 O 3 ). The occurrence of hyperleukocytosis with As 2 O 3 treatment seriously affects the early survival rate of APL patients, but no definite explanation for such a complication has been clearly established. To clarify the causes of this situation, AS3MT polymorphisms 14215 (rs3740390), 14458 (rs11191439), 27215 (rs11191446), and 35991 (rs10748835) and profiles of plasma arsenic metabolites were evaluated in a group of 54 newly diagnosed APL patients treated with single-agent As 2 O 3 . High-performance liquid chromatography-hydride generation-atomic fluorescence spectrometry (HPLC-HG-AFS) was used to determine the concentrations of plasma arsenic metabolites. Plasma arsenic methylation metabolism capacity was evaluated by the percentage of inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), primary methylation index (PMI, MMA/iAs), and secondary methylation index (SMI, DMA/ MMA
Who reads Polymorphisms in arsenic (+ 3 oxidation state) methyltransferase (AS3MT) predict the occurrence of hyperleukocytosis and arsenic metabolism in APL patients treated with As2O3?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Liu, Wen-Sheng; Wang, Xin-Yu; Lu, Jing; Zhang, Ying-Mei; Ye, Xiang-Mei; Li, Jin-Mei; Zhao, Qi-Lei; Wu, Zhi-Qiang; Zhou, Jin; Hai, Xin
- Publisher
- Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0340-5761)
- Published
- 2020
- Language
- EN
- Field
- Environmental Science (Life Sciences)