About this Medicine article

Polymorphisms in \ \ TNF\ \ and \ \ HSP‐70\ \ show a significant association with gastric cancer and duodenal ulcer by Oswaldo Partida‐Rodríguez; Javier Torres; Lourdes Flores‐Luna; Margarita Camorlinga; Miriam Nieves‐Ramírez; Eduardo Lazcano; Martha Perez‐Rodríguez is a Medicine article available to read on EtoBox.

## Abstract Tumour Necrosis Factor (TNF) and Heat Shock Protein 70 (HSP70) are important molecules in inflammatory, infectious and tumoral processes. The genes codifying these molecules are polymorphic and certain alleles have been associated with susceptibility to disease. Gastric cancer is associated with an __Helicobacter pylori__‐induced chronic inflammatory response. The aim of this work was to analyze whether polymorphisms in inflammation‐related genes are associated with the development of gastric cancer. We studied 447 Mexican adult patients including 228 with non‐atrophic gastritis, 98 with intestinal metaplasia, 63 with gastric cancer and 58 with duodenal ulcer, and 132 asymptomatic individuals as well. DNA from peripheral white blood cells was typed for the Single Nucleotide Polymorphisms (SNPs) −308 of __TNF‐α__, +252 of __TNF‐β__, +190 of __HSP70‐1__, +1267 of __HSP70‐2__ and +2437 of __HSP70‐HOM__. Compared with the asymptomatic group, we found a significant association of __TNF‐β\*A__ and __HSP70‐1\*C__ alleles with gastric cancer (OR 5.69 and 3.76, respectively) and __HSP70‐1\*C__ with duodenal ulcer (OR 3.08). Genotype __TNF‐β G/G__ showed a significant gene‐dose e

Author

Oswaldo Partida‐Rodríguez; Javier Torres; Lourdes Flores‐Luna; Margarita Camorlinga; Miriam Nieves‐Ramírez; Eduardo Lazcano; Martha Perez‐Rodríguez

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2010

Language

EN

Field

Medicine (Health Sciences)