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Progression Patterns and Site‐specific Responses in Advanced Gastric Cancer Patients Treated with Nivolumab by Toru Kadono; Satoru Iwasa; Kengo Nagashima; Kotoe Oshima; Shun Yamamoto; Hidekazu Hirano; Natsuko Okita; Hirokazu Shoji; Yoshitaka Honma; Atsuo Takashima; Ken Kato; Toshikazu Ushijima; Narikazu Boku is a Medicine article available to read on EtoBox.

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## Abstract ## Background While the efficacy of immune checkpoint inhibitors (ICIs) reportedly varies among metastatic sites and progression patterns (classified as systemic progression [SP] or mixed progression [MP]), the clinical efficacy of ICIs against gastric cancer remains unclear. The response to nivolumab depending on metastatic site and clinical outcomes according to progression pattern in patients with advanced gastric cancer was investigated retrospectively. ## Methods Seventy‐four advanced gastric cancer patients with measurable lesions who received nivolumab monotherapy between 2015 and 2020 were enrolled. Progression‐free survival (PFS), overall survival, response at each metastatic site, and clinical outcomes according to progression pattern were analyzed retrospectively. SP and MP were defined as progression in more than half of the lesions and progression in half or fewer of the lesions, respectively, in cases evaluated as progressive disease. ## Results Thirty‐five (47%) and 27 (36%) patients had SP and MP, respectively, and 12 (16%) patients experienced no progression. The progression rates of target lesions in the lung (44%) and liver (57%) were significantly hi

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Author

Toru Kadono; Satoru Iwasa; Kengo Nagashima; Kotoe Oshima; Shun Yamamoto; Hidekazu Hirano; Natsuko Okita; Hirokazu Shoji; Yoshitaka Honma; Atsuo Takashima; Ken Kato; Toshikazu Ushijima; Narikazu Boku

Publisher

Wiley

Published

2023

Language

EN

Field

Medicine (Health Sciences)