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Increased Skin Collagen Extractability and Proportions of Collagen Type III Are Not Normalized after 6 Months Healing of Human Excisional Wounds by Robins, Simon P.; Milne, George; Duncan, Alexander; Davies, Claire; Butt, Richard; Greiling, Doris; James, Ian T. is a Medicine article available to read on EtoBox.

What is Increased Skin Collagen Extractability and Proportions of Collagen Type III Are Not Normalized after 6 Months Healing of Human Excisional Wounds about?

In an attempt to identify potential staging markers of effective healing, changes in connective tissue properties were measured in a human skin excisional wound healing model in which tissue was re-excised at intervals up to 6 months after injury. The proportion of collagen III relative to collagen I increased significantly (p<0.001) up to 6 weeks after initial injury and remained elevated up to 6 months, at which time the proportion of collagen III was 70% above baseline values. Extractability of biopsy tissue collagen by pepsin increased significantly throughout the study (baseline, 32.8+/-6.8%; 6 months, 89.1+/-8.9%), with inverse changes in the mature skin cross-link, histidinohydroxylysinonorleucine (baseline, 1.18+/-0.11 mol/mol collagen; 6 months, 0.27+/-0.09 mol/mol collagen). Pyridinoline content increased over the period of the study, although remaining at relatively low concentrations (baseline, 0.037+/-0.011; 6 months, 0.063+/-0.014 mol/mol collagen), and the pyridinoline/deoxypyridinoline ratio was significantly higher (baseline, 3.5+/-0.6; 6 months, 10.3+/-2.2). Elastin content, measured as desmosine cross-links, decreased significantly in the first 3 weeks and contin

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Author

Robins, Simon P.; Milne, George; Duncan, Alexander; Davies, Claire; Butt, Richard; Greiling, Doris; James, Ian T.

Publisher

Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; Springer Science and Business Media LLC; Wiley (ISSN 0022-202X)

Published

2003

Language

EN

Field

Medicine (Health Sciences)