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Can I read Teratogen update: Pseudoephedrine on EtoBox?
Teratogen update: Pseudoephedrine by Martha M. Werler is a Medicine article available to read on EtoBox.
What is Teratogen update: Pseudoephedrine about?
## Abstract Pseudoephedrine is contained in decongestants such as the Sudafed line of products. It is an alpha‐adrenergic receptor agonist, which causes blood vessel constriction, including the therapeutic effect of reducing airflow resistance in the nasal cavity. Pseudoephedrine is one of the most commonly used medications in pregnancy, with an estimated 25% of women exposed. It has been demonstrated that alpha‐adrenergic receptor agonists slow uterine blood flow, but their effects have not been studied in relation to most reproductive outcomes in animals or humans. Two analyses of health maintenance organization pharmacy data identified 9 malformed infants among 902 first‐trimester pseudoephedrine exposures, suggesting no association with birth defects overall; however, studies of such data sets often lack sufficient power to identify risks for specific birth defects. The related compounds, epinephrine, ephedrine, and phenylephrine, have been associated with hemorrhages and cardiovascular and limb malformations in animal models. Risk of ventricular septal defects was associated with decongestant use in pregnant women in 1 recent study. The vasoconstrictive effects of these drugs
Who reads Teratogen update: Pseudoephedrine?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Martha M. Werler
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1542-0752)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)