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Incorporating Persistent Pain in Phenotypic Frailty Measurement and Prediction of Adverse Health Outcomes by Matthew C. Lohman; Karen L. Whiteman; Rebecca L. Greenberg; Martha L. Bruce is a Medicine article available to read on EtoBox.

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## Background: Frailty, a syndrome of physiological deficits, is prevalent among older adults and predicts elevated risk of adverse health outcomes. although persistent pain predicts similar risk, it is seldom considered in frailty measurement. this article evaluated the construct and predictive validity of including persistent pain in phenotypic frailty measurement. ## Methods: Frailty and persistent pain were operationalized using data from the health and retirement study (2006-2012 waves). among a subset of adults aged 65 and older (n = 3,652), we used latent class analysis to categorize frailty status and to evaluate construct validity. using cox proportional hazards models, we compared time to incident adverse outcomes (death, fall, hospitalization, institutionalization, and functional disability) between frailty classes determined by either including or excluding persistent pain as a frailty component. ## Results: In latent class models, persistent pain occurred with other frailty components in patterns consistent with a medical syndrome. frail and intermediately frail classes determined by including persistent pain were more strongly associated with all adverse outcomes comp

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Author

Matthew C. Lohman; Karen L. Whiteman; Rebecca L. Greenberg; Martha L. Bruce

Publisher

Oxford University Press (OUP)

Published

2017

Language

EN

Field

Medicine (Health Sciences)