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Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review by Oscar David Lopez-Cortes; Francisco Trujillo-Sánchez; Erika Sierra-Ruelas; Erika Martinez-Lopez; Vincenzo Di Marzo; Barbara Vizmanos is a Medicine article available to read on EtoBox.
What is Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review about?
BACKGROUND: Overweight and obesity are the consequence of a sustained positive energy balance. Twin studies show high heritability rates pointing to genetics as one of the principal risk factors. By 2022, genomic studies led to the identification of almost 300 obesity-associated variants that could help to fill the gap of the high heritability rates. The endocannabinoid system is a critical regulator of metabolism for its effects on the central nervous system and peripheral tissues. Fatty acid amide hydrolase (FAAH) is a key enzyme in the inactivation of one of the two endocannabinoids, anandamide, and of its congeners. The rs324420 variant within the FAAH gene is a nucleotide missense change at position 385 from cytosine to adenine, resulting in a non-synonymous amino acid substitution from proline to threonine in the FAAH enzyme. This change increases sensitivity to proteolytic degradation, leading to reduced FAAH levels and increased levels of anandamide, associated with obesity-related traits. However, association studies of this variant with metabolic parameters have found conflicting results. This work aims to perform a systematic review of the existing literature on the asso
Who reads Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Oscar David Lopez-Cortes; Francisco Trujillo-Sánchez; Erika Sierra-Ruelas; Erika Martinez-Lopez; Vincenzo Di Marzo; Barbara Vizmanos
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)