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Dopaminergic activity in depressed smokers: A positron emission tomography study by Usoa E. Busto; Laura Redden; Helen Mayberg; Shitij Kapur; Sylvain Houle; Laurie A. Zawertailo is a Neuroscience article available to read on EtoBox.

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## Abstract Tobacco dependence is highly prevalent in depressed patients. We assessed changes in [^11^C]‐raclopride binding potential (BP) using positron emission tomography (PET) before and after the oral administration of __d__‐amphetamine in healthy controls and unmedicated patients with current depression with and without current tobacco dependence. Over a single study day 2 [^11^C]‐raclopride positron emission tomography scans were taken in 38 subjects: at baseline and 2 h following oral __d__‐amphetamine 30 mg. Twenty controls (9 smokers, 11 nonsmokers) and 18 subjects with current major depressive episode (8 smokers, 10 non‐smokers). Striatal [^11^C]‐raclopride binding potential was measured before and after __d__‐amphetamine administration. Depressed smokers had a lower baseline [^11^C]‐raclopride binding potential compared with both control non‐smokers (__P__ < 0.007) and depressed non‐smokers (__P__ < 0.001). There was a main effect of smoking status on amphetamine‐induced change in [^11^C]‐raclopride binding potential (__P__ < 0.02), but no main effect of depression. This may be due to a floor effect because of the low BP at baseline. Depressed subjects reported signific

Who reads Dopaminergic activity in depressed smokers: A positron emission tomography study?

Author

Usoa E. Busto; Laura Redden; Helen Mayberg; Shitij Kapur; Sylvain Houle; Laurie A. Zawertailo

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

2009

Language

EN

Field

Neuroscience (Life Sciences)