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Impact of Fiber Characteristics on the Interfacial Interaction of Mammalian Cells and Bacteria by Helna M. Baby; John Joseph; Maneesha K. Suresh; Raja Biswas; Deepthy Menon is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Impact of Fiber Characteristics on the Interfacial Interaction of Mammalian Cells and Bacteria about?

An imperative requisite of tissue-engineered scaffolds is to promote host cell regeneration and concomitantly thwart microbial growth. Antibacterial agents are often added to prevent implant-related infections, which, however, aggravates the risk of bacterial resistance. For the first time, we report a fiber-based platform that selectively promotes the growth of mammalian cells and alleviates bacteria by varying fiber size, orientation, and material of polymeric yarns. The interactions of Gram-positive and -negative bacterial species with mammalian mesenchymal stem cells (MSC) were investigated on poly-€-caprolactone (PCL) yarns, polyethylene terephthalate (PET), poly-L-lactic acid (PLLA), and cotton. Various yarn configurations were studied by altering the fiber diameter (from nano- to microscale) and fiber orientations (aligned, twisted, and random) of PCL yarns. PCL nanofibrous yarn decreased the adhesion of S. aureus and E. coli, with a 2.7-fold and 1.5-fold reduction, respectively, compared to PCL microfibrous yarn. Among different fiber orientations, nanoaligned fibers resulted in an 8-fold and 30-fold reduction of S. aureus and E. coli adhesion compared to random fibers. Mor

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Author

Helna M. Baby; John Joseph; Maneesha K. Suresh; Raja Biswas; Deepthy Menon

Publisher

MDPI AG

Published

2023

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)