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The document discusses the prevalence and impact of hematological malignancies, highlighting that they accounted for 106,200 new cases in the U.S. in 2003 and approximately 5.6% of cancer-related deaths in Mexico in 2001. It emphasizes the role of epigenetic changes, particularly DNA methylation and histone acetylation, in the carcinogenesis of these malignancies, noting that such alterations can lead to gene silencing and contribute to tumor progression. The review also calls for a shift in research focus

Author

Cicero Silva

Language

EN