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Lower Extremity Ischemia, Calf Skeletal Muscle Characteristics, and Functional Impairment in Peripheral Arterial Disease by Mary M. McDermott; Frederick Hoff; Luigi Ferrucci; William H. Pearce; Jack M. Guralnik; Lu Tian; Kiang Liu; Joseph R. Schneider; Leena Sharma; Jin Tan; Michael H. Criqui is a Medicine article available to read on EtoBox.

What is Lower Extremity Ischemia, Calf Skeletal Muscle Characteristics, and Functional Impairment in Peripheral Arterial Disease about?

**OBJECTIVES:** To determine whether lower ankle brachial index (ABI) levels are associated with lower calf skeletal muscle area and higher calf muscle percentage fat in persons with and without lower extremity peripheral arterial disease (PAD). **DESIGN:** Cross‐sectional. **SETTING:** Three Chicago‐area medical centers. **PARTICIPANTS:** Four hundred thirty‐nine persons with PAD (ABI<0.90) and 265 without PAD (ABI 0.90–1.30). **MEASUREMENTS:** Calf muscle cross‐sectional area and the percentage of fat in calf muscle were measured using computed tomography at 66.7% of the distance between the distal and proximal tibia. Physical activity was measured using an accelerometer. Functional measures included the 6‐minute walk, 4‐meter walking speed, and the Short Physical Performance Battery (SPPB). **RESULTS:** Adjusting for age, sex, race, comorbidities, and other potential confounders, lower ABI values were associated with lower calf muscle area (ABI<0.50, 5,193 mm^2^; ABI 0.50–0.90, 5,536 mm^2^; ABI 0.91–1.30, 5,941 mm^2^; __P__ for trend<.001). These significant associations remained after additional adjustment for physical activity. In participants with PAD, lower calf muscle

Who reads Lower Extremity Ischemia, Calf Skeletal Muscle Characteristics, and Functional Impairment in Peripheral Arterial Disease?

Author

Mary M. McDermott; Frederick Hoff; Luigi Ferrucci; William H. Pearce; Jack M. Guralnik; Lu Tian; Kiang Liu; Joseph R. Schneider; Leena Sharma; Jin Tan; Michael H. Criqui

Publisher

Wiley

Published

2007

Language

EN

Field

Medicine (Health Sciences)