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Glucocorticoids and Cognitive Function: a Walkthrough in Endogenous and Exogenous Alterations by D. De Alcubierre; D. Ferrari; G. Mauro; A. M. Isidori; J. W. Tomlinson; R. Pofi is a Medicine article available to read on EtoBox.

What is Glucocorticoids and Cognitive Function: a Walkthrough in Endogenous and Exogenous Alterations about?

## Purpose The hypothalamic–pituitary–adrenal (HPA) axis exerts many actions on the central nervous system (CNS) aside from stress regulation. Glucocorticoids (GCs) play an important role in affecting several cognitive functions through the effects on both glucocorticoid (GR) and mineralocorticoid receptors (MR). In this review, we aim to unravel the spectrum of cognitive dysfunction secondary to derangement of circulating levels of endogenous and exogenous glucocorticoids. ## Methods All relevant human prospective and retrospective studies published up to 2022 in PubMed reporting information on HPA disorders, GCs, and cognition were included. ## Results Cognitive impairment is commonly found in GC-related disorders. The main brain areas affected are the hippocampus and pre-frontal cortex, with memory being the most affected domain. Disease duration, circadian rhythm disruption, circulating GCs levels, and unbalanced MR/GR activation are all risk factors for cognitive decline in these patients, albeit with conflicting data among different conditions. Lack of normalization of cognitive dysfunction after treatment is potentially attributable to GC-dependent structural brain alteratio

Who reads Glucocorticoids and Cognitive Function: a Walkthrough in Endogenous and Exogenous Alterations?

Author

D. De Alcubierre; D. Ferrari; G. Mauro; A. M. Isidori; J. W. Tomlinson; R. Pofi

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)