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Gc-globulin and Prognosis in Acute Liver Failure by Frank V. Schiødt; Lorenzo Rossaro; Richard T. Stravitz; A. Obaid Shakil; Raymond T. Chung; William M. Lee; Acute Liver Failure Study Group is a Medicine article available to read on EtoBox.

What is Gc-globulin and Prognosis in Acute Liver Failure about?

Serum concentrations of the actin scavenger Gc-globulin are reduced in acute liver failure (ALF). Prospectively, we tested Gc-globulin's value to predict outcome following ALF using sera from 182 patients with ALF from the U.S. ALF Study Group. Admission serum levels of Gc-globulin (normal range: 350-500 mg/L) were studied by an immunonephelometric method. The median (range) serum Gc-globulin level on admission for the entire group was 91 (5-307) mg/L. Gc-globulin levels were significantly higher in spontaneous survivors than in patients who died or underwent transplantation (113 [5-301] mg/L vs. 73 [5-307] mg/L, P < 0.001). Those surviving non-acetaminophen (paracetamol)-induced ALF without transplantation had higher Gc-globulin levels than nonsurvivors (102 [5-301] mg/L vs. 61 [5-232] mg/L, P = 0.002), whereas there was no significant difference in levels between the groups in patients with acetaminophen-induced ALF. A cutoff level of 80 mg/L in the non-acetaminophen group yielded positive and negative predictive values of 85% and 43%, respectively. The corresponding figures for the King's College criteria were 90% and 49%, respectively. In conclusion, we found that Gc-globulin l

Who reads Gc-globulin and Prognosis in Acute Liver Failure?

Author

Frank V. Schiødt; Lorenzo Rossaro; Richard T. Stravitz; A. Obaid Shakil; Raymond T. Chung; William M. Lee; Acute Liver Failure Study Group

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2005

Language

EN

Field

Medicine (Health Sciences)