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Mesenchymal Stromal Cell Senescence in Haematological Malignancies by Natalya Plakhova; Vasilios Panagopoulos; Kate Vandyke; Andrew C. W. Zannettino; Krzysztof M. Mrozik is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Mesenchymal Stromal Cell Senescence in Haematological Malignancies about?

Acute myeloid leukaemia (AML), chronic lymphocytic leukaemia (CLL), and multiple myeloma (MM) are age-related haematological malignancies with defined precursor states termed myelodysplastic syndrome (MDS), monoclonal B-cell lymphocytosis (MBL), and monoclonal gammopathy of undetermined significance (MGUS), respectively. While the progression from asymptomatic precursor states to malignancy is widely considered to be mediated by the accumulation of genetic mutations in neoplastic haematopoietic cell clones, recent studies suggest that intrinsic genetic changes, alone, may be insufficient to drive the progression to overt malignancy. Notably, studies suggest that extrinsic, microenvironmental changes in the bone marrow (BM) may also promote the transition from these precursor states to active disease. There is now enhanced focus on extrinsic, age-related changes in the BM microenvironment that accompany the development of AML, CLL, and MM. One of the most prominent changes associated with ageing is the accumulation of senescent mesenchymal stromal cells within tissues and organs. In comparison with proliferating cells, senescent cells display an altered profile of secreted factors (

Who reads Mesenchymal Stromal Cell Senescence in Haematological Malignancies?

Author

Natalya Plakhova; Vasilios Panagopoulos; Kate Vandyke; Andrew C. W. Zannettino; Krzysztof M. Mrozik

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)