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Maternal Serum Human Chorionic Gonadotrophin and Pregnancy-associated Plasma Protein a, Markers for Fetal Down Syndrome at 8–14 Weeks by M. C. M. Macintosh; R. Iles; B. Teisner; K. Sharma; T. Chard; J. G. Grudzinskas; R. H. T. Ward; F. Muller is a Medicine article available to read on EtoBox.

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## Abstract Maternal serum levels of human chorionic gonadotrophin and its subunits (intact, α, and free βhCG) and pregnancy‐associated plasma protein A (PAPP‐A) were measured in 279 women between 8 and 14 weeks' gestation. This group included 23 pregnancies in which the fetus had Down syndrome (DS), diagnosed either at birth or during the second trimester (__n__=17) or from chorionic villus sampling (CVS) (__n__=6). Normal medians were determined from the 258 apparently normal pregnancies. The median levels of intact hCG (1·4 MOM) and free βhCG (2·1 MOM) were significantly raised, whereas the median level of PAPP‐A (0·39 MOM) was significantly lower in the DS pregnancies when compared with the control group. Levels of αhCG were similar in both the control and the DS pregnancies. Analysis of samples taken prior to 14 weeks' gestation demonstrated that only PAPP‐A (0·34 MOM) was significantly altered in DS pregnancies. However, after the exclusion of DS cases diagnosed at CVS, the median intact hCG (1·56 MOM), free βhCG (2·27 MOM), and αhCG (1·8 MOM) were all raised in DS pregnancies. This emphasizes the problem of the interpretation of biochemical markers when DS cases are diagnose

Who reads Maternal Serum Human Chorionic Gonadotrophin and Pregnancy-associated Plasma Protein a, Markers for Fetal Down Syndrome at 8–14 Weeks?

Author

M. C. M. Macintosh; R. Iles; B. Teisner; K. Sharma; T. Chard; J. G. Grudzinskas; R. H. T. Ward; F. Muller

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0197-3851)

Published

1994

Language

EN

Field

Medicine (Health Sciences)