Can I read Lack of correlation between DST results and urinary MHPG in depressed inpatients on EtoBox?

Lack of correlation between DST results and urinary MHPG in depressed inpatients by H. Lo; Marie-France Poirier; T. Dennis; Chawki Benkelfat; J. M. Vanelle; C. Gay; A. Galinowski; S. Askienazy; B. Scatton is a Neuroscience article available to read on EtoBox.

What is Lack of correlation between DST results and urinary MHPG in depressed inpatients about?

Abnormalities of noradrenaline metabolism and of the activity of hypothalamic-pituitary adrenal axis (HPA) have been reported in depression. To study the possible relationship between these 2 parameters, urinary excretion of 3-methoxy-4-hydroxy-phenylethyleneglycol (MHPG) and Dexamethasone Suppression Test (DST) were analyzed in 58 depressed patients. A positive correlation was found between the age of depressed patients and 24-h urinary excretion of MHPG. Twenty-two patients (38%) were DST non suppressors. Pre-DST plasma cortisol levels were significantly higher in non suppressors than suppressors. No difference was found however between urinary MHPG levels in suppressors and non suppressors. There was no correlation between pre-DST plasma cortisol and levels of urinary excretion of MHPG. These results do not support the hypothesis of a relationship between these 2 parameters. However, when depressed patients were separated into two groups according to urinary excretion of MHPG ("high MHPG" and "low MHPG"), the "high MHPG" group included significantly more non suppressors then the "low MHPG" one. This result is not sufficient to demonstrate of link between HPA system activity and

Who reads Lack of correlation between DST results and urinary MHPG in depressed inpatients?

Author

H. Lo; Marie-France Poirier; T. Dennis; Chawki Benkelfat; J. M. Vanelle; C. Gay; A. Galinowski; S. Askienazy; B. Scatton

Published

1987

Language

EN

Field

Neuroscience (Life Sciences)