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Self-reported adherence versus pill count in Parkinson's disease: The NET-PD experience by Jordan J. Elm; Cornelia Kamp; Barbara C. Tilley; Paulo Guimaraes; Debbie Fraser; Patricia Deppen; Alicia Brocht; Chris Weaver; Susan Bennett; NINDS NET‐PD Investigators and Coordinators is a Medicine article available to read on EtoBox.
What is Self-reported adherence versus pill count in Parkinson's disease: The NET-PD experience about?
## Abstract ## Purpose To compare the Morisky medication adherence questionnaire to pill counts as measures of adherence in the NET‐PD futility clinical trials. Background: Like in other chronic diseases, non‐adherence with medications occurs in Parkinson's disease (PD), although nonadherence has not been of significant concern in most PD clinical trials. The most common approach to assessment is to do a pill count at each visit. The simple, 4‐question Morisky medication adherence questionnaire may provide an alternative approach to monitoring treatment adherence in PD. ## Methods Adherence data from two NET‐PD Phase II clinical trials enrolling a total of 413 participants were analyzed. The association between demographic and clinical characteristics and adherence was explored. ## Results Ninety‐percent of participants took 80% or more of the study drug. However, the Morisky medication adherence questionnaires showed 56% report high and 44% report medium adherence. Agreement between the two measures is fair (ICC = 0.40). ## Conclusions Overall adherence as assessed by pill count appears high. The Morisky medication adherence questionnaire may be useful in PD clinical trials, since
Who reads Self-reported adherence versus pill count in Parkinson's disease: The NET-PD experience?
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- Author
- Jordan J. Elm; Cornelia Kamp; Barbara C. Tilley; Paulo Guimaraes; Debbie Fraser; Patricia Deppen; Alicia Brocht; Chris Weaver; Susan Bennett; NINDS NET‐PD Investigators and Coordinators
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)