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Curcumin Mediates Attenuation of Pro-inflammatory Interferon γ and Interleukin 17 Cytokine Responses in Psoriatic Disease, Strengthening Its Role as a Dietary Immunosuppressant by Dimitrios Ν. Skyvalidas; Athanasios Mavropoulos; Sotirios Tsiogkas; Efthymios Dardiotis; Christos Liaskos; Zissis Mamuris; Angeliki Roussaki-Schulze; Lazaros I. Sakkas; Efterpi Zafiriou; Dimitrios P. Bogdanos is a Medicine article available to read on EtoBox.
What is Curcumin Mediates Attenuation of Pro-inflammatory Interferon γ and Interleukin 17 Cytokine Responses in Psoriatic Disease, Strengthening Its Role as a Dietary Immunosuppressant about?
Curcumin exhibits anti-inflammatory properties and has been used for centuries in traditional medicine and as dietary supplement. Data from clinical trials has strengthened the notion that curcumin may exert an anti-inflammatory and immunosuppressive role in patients with psoriatic disease, but its mode of action has remained elusive. We hypothesized that curcumin could inhibit interferon (IFN)-γ and interleukin (IL)-17 production in peripheral blood mononuclear cells from patients with psoriasis and psoriatic arthritis (PsA). To this end, we assessed the in vitro effect of curcumin on IFN-γ production by cluster differentiation (CD)4(+), CD8(+) T cells, natural killer (NK) and NKT cells and on IL-17 production by CD4(+) T cells from 34 patients with psoriatic disease (22 with psoriasis and 12 with PsA); 15 normal subjects were included as healthy controls. We also assessed the effect of curcumin on signal transducer and activator of transcription (STAT)3 activation. Curcumin significantly decreased, in a dose dependent manner, IFNγ-production by CD4(+) and CD8(+) T cells, and NK and NKT cells in patients with psoriatic disease and healthy controls. It also decreased IL-17 producti
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- Author
- Dimitrios Ν. Skyvalidas; Athanasios Mavropoulos; Sotirios Tsiogkas; Efthymios Dardiotis; Christos Liaskos; Zissis Mamuris; Angeliki Roussaki-Schulze; Lazaros I. Sakkas; Efterpi Zafiriou; Dimitrios P. Bogdanos
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0271-5317)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)