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Elevated levels of HER-2/neu and androgen receptor in clinically localized prostate cancer identifies metastatic potential by Carmela Ricciardelli; Michael W. Jackson; Catherine S. Choong; Jürgen Stahl; Villis R. Marshall; David J. Horsfall; Wayne D. Tilley is a Medicine article available to read on EtoBox.
What is Elevated levels of HER-2/neu and androgen receptor in clinically localized prostate cancer identifies metastatic potential about?
## Abstract ## BACKGROUND In this study, we investigated the expression of HER‐2/__neu__ and AR in clinically organ‐confined prostate cancer to determine whether alterations in these signaling pathways contribute to the development of metastatic disease. ## METHODS HER‐2/__neu__ and AR immunoreactivity were evaluated in archived prostatic tissues obtained from 53 men with clinically organ‐confined disease who underwent radical prostatectomy. Associations between AR and HER‐2/__neu__ immunostaining and disease outcome were determined. ## RESULTS Seventy percent (37/53) of tumors exhibited high levels of HER‐2/__neu__ immunostaining and 68% (36/53) of tumors had elevated AR levels. Patients with high levels of both HER‐2/__neu__ and AR had the highest rate of PSA failure (56%, 15/27) compared with no PSA failures amongst seven patients with low levels of both HER‐2/__neu__ and AR (log rank statistic 7.69, __P__ = 0.021). Concurrent high levels of HER‐2/__neu__ and AR expression were significantly associated with high pathological stage (__P__ = 0.027) and development of metastatic disease (__P__ = 0.022). ## CONCLUSIONS These findings support the notion that both the HER‐2/__neu__ an
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- Author
- Carmela Ricciardelli; Michael W. Jackson; Catherine S. Choong; Jürgen Stahl; Villis R. Marshall; David J. Horsfall; Wayne D. Tilley
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)