Can I read Outcomes of pregnancy in women with cystic fibrosis (CF) taking CFTR modulators – an international survey on EtoBox?

Outcomes of pregnancy in women with cystic fibrosis (CF) taking CFTR modulators – an international survey by Nash, Edward F; Middleton, Peter G; Taylor-Cousar, Jennifer L is a Medicine article available to read on EtoBox.

What is Outcomes of pregnancy in women with cystic fibrosis (CF) taking CFTR modulators – an international survey about?

## Background: As their long-term prognosis improves, women with cf are increasingly choosing to have children, but the safety of cftr modulators in pregnancy and breastfeeding is currently unknown. ## Methods: A survey was sent to lead clinicians of adult cf centres in europe, the united kingdom (uk), united states of america (usa), australia and israel requesting anonymised data on pregnancy outcomes in women using cftr modulators before and during pregnancy and lactation. ## Results: We identified 64 pregnancies in 61 women taking iva (n = 31), lum/iva (n = 26) or tez/iva (n = 7), resulting in 60 live births. in 44 pregnancies, cftr modulators were either continued throughout pregnancy or temporarily stopped and then restarted. two maternal complications were deemed related to cftr modulator therapy; cessation of modulator therapy resulted in clinical decline in 9 women prompting resumption of therapy during pregnancy. no modulator-related complications were reported in infants exposed in utero and/or during breastfeeding. ## Conclusions: Cftr modulators were reported to be generally well tolerated in pregnancy and breastfeeding, with only 2 maternal complications that were deem

Who reads Outcomes of pregnancy in women with cystic fibrosis (CF) taking CFTR modulators – an international survey?

Author

Nash, Edward F; Middleton, Peter G; Taylor-Cousar, Jennifer L

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1569-1993)

Published

2020

Language

EN

Field

Medicine (Health Sciences)