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Comprehensive analysis of SARS‐CoV‐2 antibody dynamics in New Zealand by Whitcombe, Alana L (author);McGregor, Reuben (author);Craigie, Alyson (author);James, Alex (author);Charlewood, Richard (author);Lorenz, Natalie (author);Dickson, James MJ (author);Sheen, Campbell R (author);Koch, Barbara (author);Fox‐Lewis, Shivani (author);McAuliffe, Gary (author);Roberts, Sally A (author);Morpeth, Susan C (author);Taylor, Susan (author);Webb, Rachel H (author);Jack, Susan (author);Upton, Arlo (author);Ussher, James E (author);Moreland, Nicole J (author) is a Immunology and Microbiology article available to read on EtoBox.

What is Comprehensive analysis of SARS‐CoV‐2 antibody dynamics in New Zealand about?

## Abstract ## Objectives Circulating antibodies are important markers of previous infection and immunity. Questions remain with respect to the durability and functionality of SARS‐CoV‐2 antibodies. This study explored antibody responses in recovered COVID‐19 patients in a setting where the probability of re‐exposure is effectively nil, owing to New Zealand's successful elimination strategy. ## Methods A triplex bead‐based assay that detects antibody isotype (IgG, IgM and IgA) and subclass (IgG1, IgG2, IgG3 and IgG4) responses against Nucleocapsid (N) protein, the receptor binding domain (RBD) and Spike (S) protein of SARS‐CoV‐2 was developed. After establishing baseline levels with pre‐pandemic control sera (__n__ = 113), samples from PCR‐confirmed COVID‐19 patients with mild–moderate disease (__n__ = 189) collected up to 8 months post‐infection were examined. The relationship between antigen‐specific antibodies and neutralising antibodies (NAbs) was explored with a surrogate neutralisation assay that quantifies inhibition of the RBD/hACE‐2 interaction. ## Results While most individuals had broad isotype and subclass responses to each antigen shortly after infection, only RBD and

Who reads Comprehensive analysis of SARS‐CoV‐2 antibody dynamics in New Zealand?

It is typically read by researchers, students, and practitioners in Immunology and Microbiology.

Author
Whitcombe, Alana L (author);McGregor, Reuben (author);Craigie, Alyson (author);James, Alex (author);Charlewood, Richard (author);Lorenz, Natalie (author);Dickson, James MJ (author);Sheen, Campbell R (author);Koch, Barbara (author);Fox‐Lewis, Shivani (author);McAuliffe, Gary (author);Roberts, Sally A (author);Morpeth, Susan C (author);Taylor, Susan (author);Webb, Rachel H (author);Jack, Susan (author);Upton, Arlo (author);Ussher, James E (author);Moreland, Nicole J (author)
Publisher
Wiley
Published
2021
Language
EN
Field
Immunology and Microbiology (Life Sciences)

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