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Comparison of Morphometric, Structural, Mechanical, and Physiologic Characteristics of Human Superficial Femoral and Popliteal Arteries by Jadidi, Majid; Razian, Sayed Ahmadreza; Anttila, Eric; Doan, Tyler; Adamson, Josiah; Pipinos, Margarita; Kamenskiy, Alexey is a Engineering article available to read on EtoBox.

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Peripheral arterial disease differentially affects the superficial femoral (SFA) and the popliteal (PA) arteries, but their morphometric, structural, mechanical, and physiologic differences are poorly understood. SFAs and PAs from 125 human subjects (age 13-92, average 52±17 years) were compared in terms of radii, wall thickness, and opening angles. Structure and vascular disease were quantified using histology, mechanical properties were determined with planar biaxial extension, and constitutive modeling was used to calculate the physiologic stress-stretch state, elastic energy, and the circumferential physiologic stiffness. SFAs had larger radii than PAs, and both segments widened with age. Young SFAs were 5% thicker, but in old subjects the PAs were thicker. Circumferential (SFA: 96→193°, PA: 105→139°) and longitudinal (SFA: 139→306°, PA: 133→320°) opening angles increased with age in both segments. PAs were more diseased than SFAs and had 11% thicker intima. With age, intimal thickness increased 8.5-fold, but medial thickness remained unchanged (620μm) in both arteries. SFAs had 30% more elastin than the PAs, and its density decreased ~50% with age. SFAs were more compliant tha

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Author

Jadidi, Majid; Razian, Sayed Ahmadreza; Anttila, Eric; Doan, Tyler; Adamson, Josiah; Pipinos, Margarita; Kamenskiy, Alexey

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1742-7061)

Published

2020

Language

EN

Field

Engineering (Physical Sciences)