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Prognostic Value of Myocardial Flow Reserve Obtained by 82-Rubidium Positron Emission Tomography in Long-term Follow-up After Heart Transplantation by Lærke Marie Nelson; Thomas Emil Christensen; Kasper Rossing; Philip Hasbak; Finn Gustafsson is a Medicine article available to read on EtoBox.
What is Prognostic Value of Myocardial Flow Reserve Obtained by 82-Rubidium Positron Emission Tomography in Long-term Follow-up After Heart Transplantation about?
## Background: Cardiac allograft vasculopathy (cav) is a leading cause of death following heart transplantation (htx) and non-invasive prognostic methods in long-term cav surveillance are needed. we evaluated the prognostic value of myocardial flow reserve (mfr) obtained by 82-rubidium (^82^rb) positron emission tomography (pet). ## Methods: Recipients undergoing dynamic rest-stress ^82^rb pet between april 2013 and june 2017 were retrospectively evaluated in a single-center study. evaluation by pet included quantitative myocardial blood flow and semiquantitative myocardial perfusion imaging. patients were grouped by mfr (mfr ≤ 2.0 vs mfr > 2.0) and the primary outcome was all-cause mortality. ## Results: A total of 50 patients (68% men, median age 57 [iqr: 43 to 68]) were included. median time from htx to pet was 10.0 (6.7 to 16.0) years. in 58% of patients cav was documented prior to pet. during a median follow-up of 3.6 (2.3 to 4.3) years 12 events occurred. survival probability by kaplan-meier method was significantly higher in the high-mfr group (log-rank p = .02). revascularization (n = 1), new cav diagnosis (n = 1), and graft failure (n = 4) were more frequent in low-mfr pat
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- Author
- Lærke Marie Nelson; Thomas Emil Christensen; Kasper Rossing; Philip Hasbak; Finn Gustafsson
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)