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Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles by Rongqin Huang; Liang Han; Jianhua Li; Feiliang Ren; Weilun Ke; Chen Jiang; Yuanying Pei is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles about?

## Abstract ## Background Nonviral gene therapy of chronic degenerative diseases such as Parkinson's disease (PD) is a great challenge as a result of the low tranfection efficiency of nonviral gene vectors. We previously constructed a lactoferrin (Lf)‐modified vector, which was demonstrated to be potential for brain gene delivery both __in vitro__ and __in vivo__. In the present study, this type of vector was applied to load human glial cell line‐derived neurotrophic factor gene (__hGDNF__). ## Methods A rat PD model was constructed by the unilateral lesion of striatum using 6‐hydroxydopamine (6‐OHDA). Lf‐modified nanoparticles (NPs) were prepared and characterized. Neuroprotective effects of Lf‐modified NPs were examined in the 6‐OHDA‐lesioned PD model via a regimen of multiple dosing intravenous administrations. ## Results The size of Lf‐modified NPs was 196 ± 10.1 nm, whereas the zeta potential value was 29.35 ± 3.27 mV. Lf‐modified NPs could protect themselves from heparin displacement and DNase digestion. The results of the neuroprotective evaluation show that increasing the number of injections of Lf‐modified NPs loading __hGDNF__ improved locomotor activity, reduced dopamine

Who reads Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles?

Author

Rongqin Huang; Liang Han; Jianhua Li; Feiliang Ren; Weilun Ke; Chen Jiang; Yuanying Pei

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1099-498X)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)