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Molecular Aspects Of Papovaviruses (developments In Molecular Virology) by Melvin L. DePamphilis (auth.), Yosef Aloni (eds.) is a nonfiction available to read on EtoBox.

What is Molecular Aspects Of Papovaviruses (developments In Molecular Virology) about?

It is almost twenty years since the first DNA tumor virus meeting was held at Cold Spring Harbor. At this meeting studies on three tumor viruses were discussed: the papovaviruses, the adenoviruses and the herpesviruses. The present series Developments in Molecular Virology chose to reverse this sequence by first publishing books on the herpesviruses, followed by adenoviruses, and only now the papo­ vaviruses. All the DNA tumor viruses gained their original reputation by serving as model systems in animal cells for studying gene expression and gene regulation, but SV40 and polyoma have been the jewel in the crown in these studies, as A phage was for the study of prokaryotes. SV40 was the first DNA tumor virus to be completely sequenced that enabled the definition of the cis controlling elements in DNA replication and transcription. I am continuously fascinated by the organization of the SV40 and polyoma genomes. Although they contain about 5000 bp that encode for only 6 to 7 proteins, the mechanisms which regulated their gene expression are varied and include almost any other type of gene regulation found today to regulate eukaryotic genes. Just to mention two: (i) the early promote

Who reads Molecular Aspects Of Papovaviruses (developments In Molecular Virology)?

Author

Melvin L. DePamphilis (auth.), Yosef Aloni (eds.)

Publisher

Springer US

Published

1987

Language

EN

ISBN

9781461292371

Category

nonfiction

Subjects

Science, Medical, Biology