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Copper‐Catalyzed C4‐selective Carboxylation of Pyridines with CO~2~ via Pyridylphosphonium Salts by Shibiao Tang; Zezhao Liu; Jiakai Zhang; Bin Li; Baiquan Wang is a Chemistry article available to read on EtoBox.

What is Copper‐Catalyzed C4‐selective Carboxylation of Pyridines with CO~2~ via Pyridylphosphonium Salts about?

## Abstract Pyridine motifs are widespread pharmacophores in many drugs. Installing various substituents through pyridine C−H bond functionalization is significant for new drug design and discovery. Developments of late‐stage functionalization reactions enrich the strategies for selective functionalization of pyridines. However, late‐stage C−H carboxylation of pyridines is a long‐standing challenge, especially selectively carboxylation with CO~2~ on pyridine motifs. Herein, we describe a practical method for C4−H carboxylation of pyridines via one‐pot C−H phosphination and copper‐catalyzed carboxylation of the resulted phosphonium salts with CO~2~. The reaction is conducted under mild conditions and compatible with multiple active groups and several pyridine drugs, providing diverse valuable isonicotinic acid compounds, demonstrating the application potential of this strategy.

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Author

Shibiao Tang; Zezhao Liu; Jiakai Zhang; Bin Li; Baiquan Wang

Publisher

Wiley

Published

2024

Language

EN

Field

Chemistry (Physical Sciences)