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Lentiviral-mediated Gene Transfer of Brain-derived Neurotrophic Factor Is Neuroprotective in a Mouse Model of Neonatal Excitotoxic Challenge by Alexis-Pierre Bemelmans; Isabelle Husson; Muriel Jaquet; Jacques Mallet; Barry E. Kosofsky; Pierre Gressens is a Neuroscience article available to read on EtoBox.
What is Lentiviral-mediated Gene Transfer of Brain-derived Neurotrophic Factor Is Neuroprotective in a Mouse Model of Neonatal Excitotoxic Challenge about?
Excitotoxicity may be a critical factor in the formation of brain lesions associated with cerebral palsy. When injected into the murine neopallium at postnatal day 5, the glutamatergic analog N-methyl-D-aspartate (NMDA) produces transcortical neuronal death and periventricular white matter cysts, which mimic brain damage observed in human term and preterm neonates at risk for developing cerebral palsy. We previously showed that intracerebral injection of brain-derived neurotrophic factor (BDNF) was neuroprotective in this model. Because BDNF does not easily cross the blood-brain barrier, alternative strategies to avoid repeated intracerebral injections of BDNF should be tested, particularly when the goal of such translational research is ultimately to achieve clinical application. The goal of the present study was to assess the protective role of lentiviralmediated gene transfer of BDNF against excitotoxic lesions induced by NMDA in newborn mice. We first assessed the biological activity of BDNF gene transfer in vitro and determined the efficiency of gene transfer in our in vivo model. We next administered the BDNFexpressing vector by intracerebral injection in neonatal mice, 3 day
Who reads Lentiviral-mediated Gene Transfer of Brain-derived Neurotrophic Factor Is Neuroprotective in a Mouse Model of Neonatal Excitotoxic Challenge?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Alexis-Pierre Bemelmans; Isabelle Husson; Muriel Jaquet; Jacques Mallet; Barry E. Kosofsky; Pierre Gressens
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 2006
- Language
- EN
- Field
- Neuroscience (Life Sciences)