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Can I read SAS CARE 2 – a randomized study of CPAP in patients with obstructive sleep disordered breathing following ischemic stroke or transient ischemic attack on EtoBox?

SAS CARE 2 – a randomized study of CPAP in patients with obstructive sleep disordered breathing following ischemic stroke or transient ischemic attack by Bernasconi, C.; Ott, S.R.; Fanfulla, F.; Miano, S.; Horvath, T.; Seiler, A.; Cereda, C.W.; Brill, A.-K.; Young, P.; Nobili, L.; Manconi, M.; Bassetti, C.L.A. is a Psychology article available to read on EtoBox.

What is SAS CARE 2 – a randomized study of CPAP in patients with obstructive sleep disordered breathing following ischemic stroke or transient ischemic attack about?

## Objective/background The benefit of Continuous Positive Airway Pressure (CPAP) treatment following ischemic stroke in patients with obstructive sleep-disordered breathing (SDB) is unclear. We set out to investigate this open question in a randomized controlled trial as part of the SAS-CARE study. ## Patients/methods. Non-sleepy patients (ESS < 10) with ischemic stroke or transient ischemic attack (TIA) and obstructive SDB (AHI ≥ 20) 3 months post-stroke were randomized 1:1 to CPAP treatment (CPAP+) or standard care. Primary outcome was the occurrence of vascular events (TIA/stroke, myocardial infarction/revascularization, hospitalization for heart failure or unstable angina) or death within 24 months post-stroke. Secondary outcomes included Modified Rankin Scale (mRS) and Barthel Index. ## Results Among 238 SAS-CARE patients 41 (17%) non-sleepy obstructive SDB patients were randomized to CPAP (n = 19) or standard care (n = 22). Most patients (80%) had stroke and were males (78%), mean age was 64 ± 7 years and mean NIHSS score 0.6 ± 1.0 (range: 0–5). The primary endpoint was met by one patient in the standard care arm (a new stroke). In an intent-to treat analysis disregarding ad

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Author
Bernasconi, C.; Ott, S.R.; Fanfulla, F.; Miano, S.; Horvath, T.; Seiler, A.; Cereda, C.W.; Brill, A.-K.; Young, P.; Nobili, L.; Manconi, M.; Bassetti, C.L.A.
Publisher
Elsevier ; Elsevier BV; Amsterdam: Elsevier B.V. (ISSN 2590-1427)
Published
2020
Language
EN
Field
Psychology (Social Sciences)

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Browse all works by Bernasconi, C.; Ott, S.R.; Fanfulla, F.; Miano, S.; Horvath, T.; Seiler, A.; Cereda, C.W.; Brill, A.-K.; Young, P.; Nobili, L.; Manconi, M.; Bassetti, C.L.A.