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Distinctive Oculomotor Behaviors in Alzheimer's Disease and Frontotemporal Dementia by Carmen Lage; Sara López-García; Alexandre Bejanin; Martha Kazimierczak; Ignacio Aracil-Bolaños; Alberto Calvo-Córdoba; Ana Pozueta; María García-Martínez; Andrea Fernández-Rodríguez; María Bravo-González; Julio Jiménez-Bonilla; Ignacio Banzo; Juan Irure-Ventura; Jordi Pegueroles; Ignacio Illán-Gala; Juan Fortea; Eloy Rodríguez-Rodríguez; Alberto Lleó-Bisa; Cecilia E. García-Cena; Pascual Sánchez-Juan is a Medicine article available to read on EtoBox.

What is Distinctive Oculomotor Behaviors in Alzheimer's Disease and Frontotemporal Dementia about?

Oculomotor behavior can provide insight into the integrity of widespread cortical networks, which may contribute to the differential diagnosis between Alzheimer's disease and frontotemporal dementia. Three groups of patients with Alzheimer's disease, behavioral variant of frontotemporal dementia (bvFTD) and semantic variant of primary progressive aphasia (svPPA) and a sample of cognitively unimpaired elders underwent an eye-tracking evaluation. All participants in the discovery sample, including controls, had a biomarker-supported diagnosis. Oculomotor correlates of neuropsychology and brain metabolism evaluated with 18F-FDG PET were explored. Machine-learning classification algorithms were trained for the differentiation between Alzheimer's disease, bvFTD and controls. A total of 93 subjects (33 Alzheimer's disease, 24 bvFTD, seven svPPA, and 29 controls) were included in the study. Alzheimer's disease was the most impaired group in all tests and displayed specific abnormalities in some visually-guided saccade parameters, as pursuit error and horizontal prosaccade latency, which are theoretically closely linked to posterior brain regions. BvFTD patients showed deficits especially

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Author

Carmen Lage; Sara López-García; Alexandre Bejanin; Martha Kazimierczak; Ignacio Aracil-Bolaños; Alberto Calvo-Córdoba; Ana Pozueta; María García-Martínez; Andrea Fernández-Rodríguez; María Bravo-González; Julio Jiménez-Bonilla; Ignacio Banzo; Juan Irure-Ventura; Jordi Pegueroles; Ignacio Illán-Gala; Juan Fortea; Eloy Rodríguez-Rodríguez; Alberto Lleó-Bisa; Cecilia E. García-Cena; Pascual Sánchez-Juan

Publisher

Frontiers Media SA

Published

2021

Language

EN

Field

Medicine (Health Sciences)