Opening book details…
Can I read Selenoprotein P, as a predictor for evaluating gemcitabine resistance in human pancreatic cancer cells on EtoBox?
Selenoprotein P, as a predictor for evaluating gemcitabine resistance in human pancreatic cancer cells by Shin‐ichiro Maehara; Shinji Tanaka; Mitsuo Shimada; Ken Shirabe; Yoshiro Saito; Kazuhiko Takahashi; Yoshihiko Maehara is a Medicine article available to read on EtoBox.
What is Selenoprotein P, as a predictor for evaluating gemcitabine resistance in human pancreatic cancer cells about?
## Abstract Gemcitabine is a new standard chemotherapeutic agent used in the treatment of pancreatic cancer, but the mechanisms of gemcitabine sensitivity are still controversial. In our study to determine a mechanism that regulates gemcitabine sensitivity, we carried out molecular analysis on the susceptibility of the pancreatic cancer cells. Using a gemcitabine‐sensitive pancreatic cancer cell line KLM1, we established a resistant cell line KLM1‐R exhibiting a 20‐fold IC~50~‐value (the concentration of gemcitabine causing 50% growth inhibition). Microarray analysis of genes showed specific expression of __selenoprotein P__, one of the anti‐oxidants, in the KLM1‐R cell line but not in the KLM1 cell line. Administration of selenoprotein P inhibited the gemcitabine‐induced cytotoxicity in the pancreatic cell lines. The levels of intracellular reactive oxygen species (ROS) were increased in the KLM1 cells by gemcitabine, but selenoprotein P suppressed the gemcitabine‐induced ROS levels. Furthermore interferon‐γ suppressed the expression of __selenoprotein P__ mRNA and increased intracellular ROS level, leading to the recovery of the gemcitabine sensitivity in KLM1‐R. These results su
Who reads Selenoprotein P, as a predictor for evaluating gemcitabine resistance in human pancreatic cancer cells?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shin‐ichiro Maehara; Shinji Tanaka; Mitsuo Shimada; Ken Shirabe; Yoshiro Saito; Kazuhiko Takahashi; Yoshihiko Maehara
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)