Can I read Familial migraine with vertigo: No mutations found in CACNA1A on EtoBox?

Familial migraine with vertigo: No mutations found in CACNA1A by Kim, Ji-Soo; Yue, Qing; Jen, Joanna C.; Nelson, Stanley F.; Baloh, Robert W. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Familial migraine with vertigo: No mutations found in CACNA1A about?

We searched for mutations in the voltagegated calcium channel gene, CACNA1A, in nine propositi of families with migraine headaches and episodic vertigo inherited in an autosomal dominant pattern. All 47 exons and flanking introns in CACNA1A were subjected to single-strand conformation polymorphism analysis of polymerase chain reaction-amplified genomic DNA. Exons with aberrantly migrating fragments were sequenced using standard techniques. We also determined the CAG repeat length at the 3 end of CACNA1A. Several polymorphisms were found but no mutations identified in any of the 47 exons of the 9 patients. No index-case had a CAG repeat length greater than 13 (normal <17). Mutations in CACNA1A are not common in families with migraine headaches and episodic vertigo. Other ion channel genes expressed in the brain and inner ear remain candidate genes.

Who reads Familial migraine with vertigo: No mutations found in CACNA1A?

Author

Kim, Ji-Soo; Yue, Qing; Jen, Joanna C.; Nelson, Stanley F.; Baloh, Robert W.

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0148-7299)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)