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The majority of severe COVID-19 patients develop anti-cardiac autoantibodies by Miklós Fagyas; Béla Nagy; Arnold Péter Ráduly; Ivetta Siket Mányiné; Lilla Mártha; Gábor Erdősi; Sándor Sipka; Enikő Enyedi; Attila Ádám Szabó; Zsófia Pólik; János Kappelmayer; Zoltán Papp; Attila Borbély; Tamás Szabó; József Balla; György Balla; Péter Bai; Attila Bácsi; Attila Tóth is a Medicine article available to read on EtoBox.

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## Abstract Severe cases of COVID-19 are characterized by an inflammatory burst, which is accompanied by multiorgan failure. The elderly population has higher risk for severe or fatal outcome for COVID-19. Inflammatory mediators facilitate the immune system to combat viral infection by producing antibodies against viral antigens. Several studies reported that the pro-inflammatory state and tissue damage in COVID-19 also promotes autoimmunity by autoantibody generation. We hypothesized that a subset of these autoantibodies targets cardiac antigens. Here we aimed to detect anti-cardiac autoantibodies in severe COVID-19 patients during hospitalization. For this purpose, 104 COVID-19 patients were recruited, while 40 heart failure patients with dilated cardiomyopathy and 20 patients with severe aortic stenosis served as controls. Patients were tested for anti-cardiac autoantibodies, using human heart homogenate as a bait. Follow-up samples were available in 29 COVID-19 patients. Anti-cardiac autoantibodies were detected in 68% (71 out of 104) of severe COVID-19 patients. Overall, 39% of COVID-19 patients had anti-cardiac IgG autoantibodies, while 51% had anti-cardiac autoantibodies of

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Author

Miklós Fagyas; Béla Nagy; Arnold Péter Ráduly; Ivetta Siket Mányiné; Lilla Mártha; Gábor Erdősi; Sándor Sipka; Enikő Enyedi; Attila Ádám Szabó; Zsófia Pólik; János Kappelmayer; Zoltán Papp; Attila Borbély; Tamás Szabó; József Balla; György Balla; Péter Bai; Attila Bácsi; Attila Tóth

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)