Can I read Resistance to prophylactic treatment with macrocyclic lactone anthelmintics in Teladorsagia circumcincta on EtoBox?

Resistance to prophylactic treatment with macrocyclic lactone anthelmintics in Teladorsagia circumcincta by I.A. Sutherland; A.E. Brown; D.M. Leathwick; S.A. Bisset is a Immunology and Microbiology article available to read on EtoBox.

What is Resistance to prophylactic treatment with macrocyclic lactone anthelmintics in Teladorsagia circumcincta about?

Sixty-four Romney ewe lambs were allocated to 12 groups on the basis of liveweight. Four groups (n = 5) were administered oral ivermectin (IVM), 4 (n = 6) oral moxidectin (MOX) and the remaining 4 (n = 5) controlled-release capsules containing IVM (IVM-CRCs). Nine and 10 days later, the groups within each treatment type were challenged with infective-stage larvae (L3) of 1 of 4 different isolates of Teladorsagia circumcincta (two doses each of 5000 L3). The first of these (S) was known to be anthelmintic-susceptible; the second (OR) was a multiple anthelmintic-resistant strain recovered from the field following therapeutic failure of both ivermectin and moxidectin and subsequently maintained in the laboratory without further anthelmintic selection; the third (R) was derived from OR but had been passaged for five generations indoors with each generation being screened with all three broad-spectrum anthelmintic classes; and the fourth (R × S) was an F1 cross between the R and S isolates. As anticipated, because of its limited residual activity, IVM had no significant effect on the establishment, 9 and 10 days post-treatment, of any of the parasite isolates. In contrast MOX, which has

Who reads Resistance to prophylactic treatment with macrocyclic lactone anthelmintics in Teladorsagia circumcincta?

Author

I.A. Sutherland; A.E. Brown; D.M. Leathwick; S.A. Bisset

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0304-4017)

Published

2003

Language

EN

Field

Immunology and Microbiology (Life Sciences)